Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking
J. Clin. Invest. Jessie R. Zhang, et al. 118:2281 doi:10.1172/JCI32561 [Go to this article.]

Figure 4
Aortic atherosclerosis in MϕNpc1^+/+ and MϕNpc1^–/– mice after 10 weeks on a high-fat diet. (A) En face images of representative aortas. Arrows denote atherosclerotic plaque. (B) Quantification of aortic intimal lesions. For each aorta, separate measurements of lesion area were performed in the arch, thoracic aorta, and abdominal aorta. Combined lesion area was significantly greater in MϕNpc1^–/– than in MϕNpc1^+/+ mice (P < 0.05). (C) Atherosclerosis at aortic origin. Frozen aortic cross-sections from representative high-fat diet–fed MϕNpc1^+/+ and MϕNpc1^–/– chimeric mice were stained with hematoxylin and Oil red O. Arrows indicate regions staining for Oil red O. Original magnification, ×10 (A); ×100 (C).